Overview
What you’ll learn
- Match testosterone, oestrogen and progesterone to their glands and roles.
- Order the events of the 28-day menstrual cycle.
- (Higher) Explain the FSH–oestrogen–LH–progesterone interaction web.
- Sort contraception into hormonal and non-hormonal and evaluate the trade-offs.
- Describe IVF and evaluate its benefits, risks and ethical issues.
- (Biology only) Match auxins, gibberellins and ethene to their effects and commercial uses.
- (Biology only) Interpret seedling-practical results in terms of auxin.
Specification checklist (AQA 8461 · Edexcel 1BI0 · OCR Gateway J247)
Statements are paraphrased from the shared DfE subject content and grouped by tier. Foundation content is studied by every student; Higher statements are examined on Higher-tier papers only, and statements badged Biology only are examined in separate (triple) Biology, not Combined Science. QuizQuip is not affiliated with AQA, Pearson Edexcel or OCR.
Foundation — every student
- 14.1Describe the roles of hormones in human reproduction, including the hormones testosterone, produced by the testes and responsible for sperm production and male secondary sexual characteristics, and oestrogen and progesterone, produced by the ovaries and involved in the menstrual cycle and female secondary sexual characteristics.
- 14.2Describe the menstrual cycle as a roughly 28-day cycle in which the uterus lining builds up, an egg is released (ovulation) at about day 14, and — if the egg is not fertilised — the lining breaks down (menstruation).
- 14.3Describe the hormones involved in the menstrual cycle: FSH from the pituitary causes a follicle to mature and stimulates oestrogen production; LH from the pituitary stimulates the release of the egg; oestrogen from the ovaries repairs the uterus lining and stimulates LH release; progesterone maintains the uterus lining and inhibits FSH and LH release.
- 14.5Explain the use of hormones in contraception: oral contraceptives containing oestrogen and progesterone inhibit FSH release so no eggs mature; slow-release methods (implants, injections, patches) deliver progesterone over months; and evaluate the benefits and risks, including possible side effects.
- 14.6Describe non-hormonal methods of contraception: barrier methods such as condoms and diaphragms, intrauterine devices (IUDs), spermicides, abstinence, and surgical sterilisation.
- 14.7Describe the use of hormones in modern reproductive technology: FSH and LH as “fertility drugs” to stimulate egg maturation and release, and in vitro fertilisation (IVF), in which eggs are collected, fertilised in the laboratory with sperm, and the resulting embryos implanted in the uterus.
- 14.8Evaluate IVF: it has allowed many couples to have children, but success rates are low, treatment is physically and emotionally stressful, hormone side effects occur, and multiple births carry risks; ethical issues include the fate of unused embryos.
- 14.9(Biology only) Describe the effects of plant hormones: auxins control cell elongation near the shoot tips and are involved in phototropisms and gravitropisms, and are used as weedkillers and rooting powders and to control dormancy; gibberellins stimulate seed germination, flowering and fruit production; ethene controls cell division and ripening, and is used in the food industry to ripen fruit.Biology only
- 14.10(Biology only) Describe the required practical investigating the effect of light or gravity on the growth of seedlings, using seedlings grown in different conditions and measuring their shoot growth, and explain the results in terms of auxin distribution.Biology only
Higher — Higher tier only
- 14.4(Higher) Explain the interactions of FSH, LH, oestrogen and progesterone in the control of the menstrual cycle, including the feedback effects of oestrogen (low levels inhibit FSH; high levels stimulate LH) and progesterone (inhibits FSH and LH).
Key points
- 1Testosterone (testes) → sperm production and male secondary characteristics. Oestrogen and progesterone (ovaries) → menstrual cycle and female secondary characteristics.
- 2The menstrual cycle is roughly 28 days: lining builds, ovulation about day 14, menstruation if no fertilisation.
- 3FSH matures the follicle; oestrogen repairs the lining; LH releases the egg; progesterone maintains the lining. (Higher) oestrogen and progesterone feed back on FSH and LH.
- 4Hormonal contraception — the pill (oestrogen + progesterone), implants, injections, patches — inhibits FSH so no egg matures. Non-hormonal: barriers, IUDs, spermicides, abstinence, sterilisation.
- 5IVF: fertility drugs (FSH/LH) → eggs collected → fertilised in the laboratory → embryos implanted. Low success rates, stress, side effects, multiple-birth risks, embryo ethics.
- 6(Biology only) Auxins elongate cells (tropisms, weedkillers, rooting powders); gibberellins germinate seeds and drive flowering/fruit; ethene ripens fruit.
Notes · 1 of 5
Reproductive hormones and puberty
Two glands, two hormone families, one shared job.
During puberty the body’s reproductive hormones switch on, driving secondary sexual characteristics and beginning the production of gametes. In males the testes produce testosterone, which stimulates sperm production and develops male secondary characteristics. In females the ovaries produce oestrogen and progesterone, which drive female secondary characteristics and run the menstrual cycle.
Both systems are coordinated from the same master gland: the pituitary, which releases FSH and LH to steer the gonads. This chapter’s hormones all hang off that hierarchy.
Notes · 2 of 5
The menstrual cycle
A 28-day clock run by four hormones.
The menstrual cycle prepares the body for a possible pregnancy roughly every 28 days. The uterus lining builds up; an egg matures in a follicle and is released at ovulation, about day 14; if the egg is not fertilised, the lining breaks down — menstruation — and the cycle restarts.
| Hormone | Source | Role |
|---|---|---|
| FSH | Pituitary | Causes a follicle to mature in the ovary; stimulates oestrogen production |
| Oestrogen | Ovaries | Repairs and builds the uterus lining; stimulates LH release |
| LH | Pituitary | Stimulates the release of the egg (ovulation) |
| Progesterone | Ovaries | Maintains the uterus lining; inhibits FSH and LH release |
(Higher) The hormones interact: rising oestrogen first suppresses FSH (so only one follicle matures) and then, above a threshold, triggers a surge of LH — the ovulation trigger. After ovulation, progesterone holds the lining and blocks further FSH and LH, keeping the cycle on hold unless fertilisation occurs. When progesterone falls, FSH rises again and the next cycle begins.
Notes · 3 of 5
Contraception
Hormonal gates and physical barriers.
Hormonal contraception works by inhibiting FSH, so no follicle matures and no egg is released. The oral contraceptive combines oestrogen and progesterone — highly effective, but oestrogen can cause side effects such as raised blood pressure; progesterone-only versions reduce some risks. Implants, injections and patches release progesterone slowly over months, avoiding daily pills.
Non-hormonal methods: barrier methods — condoms (which also protect against STIs) and diaphragms — physically block sperm; intrauterine devices (IUDs) prevent embryos implanting; spermicides kill or disable sperm; abstinence avoids intercourse; and sterilisation cuts or ties the tubes permanently.
Notes · 4 of 5
Fertility treatment and IVF
Hormones to hatch a plan — then the ethics arrive.
Some couples cannot conceive naturally. Fertility drugs give FSH and LH to stimulate the maturation and release of several eggs. In in vitro fertilisation (IVF), those eggs are collected from the ovaries and fertilised in the laboratory with sperm; one or more resulting embryos are then implanted into the uterus.
The evaluation is a GCSE staple. Benefits: IVF has allowed many couples to have children. Drawbacks: success rates are low per cycle, treatment is emotionally and physically stressful, hormone doses cause side effects, and multiple embryo implantation risks multiple births. Ethical issues include the fate of unused embryos, selection between embryos, and treatment costs.
Notes · 5 of 5
Plant hormones (Biology only)
Auxin bends, gibberellin grows, ethene ripens.
Plants coordinate with chemicals too. Auxins control cell elongation near the shoot tips. Light and gravity redistribute auxin, so shoots grow toward light (phototropism) and roots grow downward (gravitropism). Commercially, auxins serve as weedkillers (overdoses disrupt dicot growth), rooting powders (cuttings sprout roots), and agents to control dormancy in seeds and storage organs.
Gibberellins end seed dormancy and drive germination, plus flowering and fruit production — used to make seeds germinate out of season and to enlarge fruits. Ethene is a gas hormone controlling cell division and ripening: fruit is picked unripe and hard, shipped, then dosed with ethene so it ripens on the shelf just before sale.
- 1The seedlings practical
Grow cress or similar seedlings in different conditions: normal light, darkness, light from one side, or rotated (clinostat). Measure shoot length and curvature.
- 2What you see
Shoots grow toward unilateral light and against gravity; shoots in darkness grow longer (etiolated) but weak.
- 3Why
Auxin accumulates on the shaded side of a shoot, elongating those cells more, so the shoot bends toward the light; in darkness no bending occurs and cells elongate unchecked.
Revise
Key terms
The words examiners expect you to use precisely.
- Testosterone
- The hormone from the testes that drives sperm production and male secondary characteristics.
- Oestrogen
- An ovarian hormone that repairs the uterus lining and stimulates LH release.
- Progesterone
- An ovarian hormone that maintains the uterus lining and inhibits FSH and LH.
- FSH
- Pituitary hormone that matures a follicle and stimulates oestrogen production.
- LH
- Pituitary hormone that triggers the release of the egg at ovulation.
- Ovulation
- The release of a mature egg from the ovary, at about day 14 of the cycle.
Show 5 more key termsShow fewer key terms
- IVF
- In vitro fertilisation: eggs fertilised with sperm in a laboratory and embryos implanted into the uterus.
- Auxin
- A plant hormone controlling cell elongation in shoots; the basis of tropisms, weedkillers and rooting powders.Biology only
- Gibberellin
- A plant hormone stimulating germination, flowering and fruit production.Biology only
- Ethene
- A gaseous plant hormone controlling cell division and fruit ripening.Biology only
- Phototropism
- Growth of a shoot toward light, driven by auxin redistribution.Biology only
Revise
Common mistakes
Where students most often lose marks in this chapter — and what to do instead.
Mistake: Saying testosterone is produced by the ovaries.
Testosterone is a testes hormone; the ovaries make oestrogen and progesterone.
Instead: Testes → testosterone → sperm production.
Mistake: Putting ovulation at day 28.
Day 28 is when the lining breaks down; ovulation is about day 14.
Instead: Lining builds → ovulation ≈ day 14 → menstruation ≈ day 28.
Show 10 more mistakesShow fewer mistakes
Mistake: Saying progesterone stimulates LH.
Progesterone inhibits both FSH and LH; oestrogen (at high levels) stimulates LH.
Instead: Oestrogen stimulates LH; progesterone inhibits FSH and LH.
Mistake: Saying FSH directly releases the egg.
FSH matures the follicle; LH is the release trigger.
Instead: FSH matures; LH releases.
Mistake: Claiming the pill works by killing sperm.
Hormonal contraception prevents eggs maturing (no FSH); sperm-killing is spermicides.
Instead: Pill → inhibits FSH → no egg matures.
Mistake: Saying condoms are a hormonal method.
Condoms are barriers — physical blocks, no hormones.
Instead: Barriers: condoms, diaphragms. Hormonal: pill, implant, injection, patch.
Mistake: Describing IVF as fertilisation inside the mother.
"In vitro" means in glass — fertilisation happens in the laboratory.
Instead: Eggs collected → fertilised in the lab → embryos implanted.
Mistake: Ignoring IVF’s low success rate in evaluations.
IVF is not a guarantee; many cycles fail, which drives the stress and cost.
Instead: Low success rates underpin the emotional and financial burden.
Mistake: Saying auxin makes cells shrink.
Auxin promotes cell elongation — shoots bend because shaded cells grow longer.
Instead: Auxin → cell elongation; more auxin on the shaded side.
Mistake: Attributing fruit ripening to gibberellins.
Ripening is ethene; gibberellins handle germination, flowering and fruit growth.
Instead: Ethene ripens; gibberellins germinate and grow.
Mistake: Saying roots grow toward light.
Shoots are positively phototropic; roots grow downward (gravitropism) and away from light.
Instead: Shoots → light; roots → gravity.
Mistake: Forgetting that seedlings in darkness grow taller but weaker.
Etiolated growth is stretched and pale — an exam favourite result.
Instead: Darkness → long, weak, pale shoots (no light, unchecked elongation).
Check yourself
Quick quiz
30 questions with instant explanations. About 5 minutes.
Question 1 of 3
- Question 1: current question
- Question 2: not answered
- Question 3: not answered
Match reproductive hormones to roles
Sperm production is stimulated by
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Practise
Topical questions
18 exam-style questions with model answers and mark schemes.
A set of structured and calculation questions matched to this chapter, in three tiers, each with a model answer, mark scheme and examiner tip. Higher-tier and Biology-only questions are tagged.
Practise topical questionsExam practice
Practice paper
A 30-mark paper in the style of a GCSE paper, with a separate mark scheme. Give yourself 40 min.
Question paper
Chapter 14 Practice Paper
30 marks · 40 min · 5 pages
10 multiple-choice questions and structured questions with answer lines. Chapter 14: testosterone, oestrogen and progesterone, the menstrual cycle and its hormone interactions (Higher), hormonal and non-hormonal contraception, fertility treatment and IVF, and (Biology only) auxins, gibberellins, ethene and the seedlings practical.
Mark scheme
PROChapter 14 Practice Paper — mark scheme
Answers · Marking points · 3 pages
Model answers with a mark for each creditworthy point — for marking at home or in class.
How is this chapter examined?
Paper 1
1 h 45 · 100 marks
Topics 1–4: cell biology, organisation, infection and response, bioenergetics (chapters 1–10)
Paper 2
1 h 45 · 100 marks
Topics 5–7: homeostasis and response, inheritance variation and evolution, ecology (chapters 11–18)
Tiers
Foundation (grades 1–5) · Higher (grades 4–9)
Higher assumes all Foundation content; ten required practicals are examined on the papers
Want a full paper? Try the Paper 1-style (Foundation), Paper 1-style (Higher), Paper 2-style (Foundation), Paper 2-style (Higher), Required practicals practice sets.
Questions
Frequently asked questions
How do I keep FSH and LH separate?
FSH First — it matures the follicle. LH Last — it launches the egg. Alphabet in order, cycle in order.
What turns the pill into full marks?
The FSH mechanism: oestrogen and progesterone inhibit FSH, so no follicle matures and no egg is released. Then add a benefit and a side effect for the evaluation.
Which plant hormone goes with which job?
Auxin bends (and kills weeds, roots cuttings); gibberellin grows (germination, flowering, fruit size); ethene ripens. Three hormones, three verbs.
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Up next
Chapter 15: Reproduction, DNA and protein synthesis