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Chapter 8 Practice Paper: Monoclonal antibodies, plant disease and culturing — question paper

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QQ/GCSE-BIO/CH8

GCSE (9–1) · GCSE Biology (Foundation and Higher)

Chapter 8 Practice Paper

Monoclonal antibodies, plant disease and culturing

Duration: 40 minutes
Total: 30 marks
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READ THESE INSTRUCTIONS FIRST

  • Answer all questions.
  • Section A contains ten multiple-choice questions. Choose one answer, A, B, C or D, for each.
  • Section B contains structured questions. Write your answers in the spaces provided.
  • You may use a calculator.
  • The number of marks is given in brackets [ ] at the end of each question or part question.
  • The total mark for this paper is 30.

Original practice material written for the MOE GCSE Biology syllabus. It is not an official MOE or school examination paper. Chapter 8: hybridomas and monoclonal antibody uses, pregnancy tests and cancer targeting, detecting and identifying plant disease, physical, chemical and mechanical plant defences, and the culturing required practical with aseptic technique and πr² area calculations.

For Examiner’s Use
Section A/ 10
Section B/ 20
Total/ 30

Section A: Multiple-choice questions[10 marks]

Choose one answer for each question. Each question is worth 1 mark.

  1. 1

    Monoclonal antibodies all bind

    1. Aevery antigen in the blood
    2. Bone specific antigen
    3. Ctwo different antigens
    4. Donly viral antigens
    ( )
  2. 2

    A hybridoma is formed by fusing a lymphocyte with

    1. Aa red blood cell
    2. Ba platelet
    3. Ca tumour cell
    4. Da phagocyte
    ( )
  3. 3

    A pregnancy test works by detecting

    1. Aoestrogen in saliva
    2. BHCG in urine
    3. Cprogesterone in blood
    4. DLH in sweat
    ( )
  4. 4

    Which set of plant defences is correctly labelled?

    1. Athorns — chemical; cuticle — mechanical
    2. Bpoisons — physical; bark — chemical
    3. Ccellulose walls — physical; thorns — mechanical
    4. Dhairs — chemical; mimicking eggs — physical
    ( )
  5. 5

    School agar plates are incubated at about

    1. A4 °C
    2. B37 °C
    3. C60 °C
    4. D25 °C
    ( )
  6. 6

    A clear area on a bacterial plate around an antibiotic disc shows that

    1. Abacteria have been killed or prevented from growing
    2. Bthe agar is richer there
    3. Cbacteria are growing fastest there
    4. Dthe disc has melted
    ( )
  7. 7

    A colony 8 mm across has an area of about

    1. A50 mm²
    2. B25 mm²
    3. C100 mm²
    4. D201 mm²
    ( )
  8. 8

    Identifying a plant pathogen definitively requires

    1. Aa photograph of the leaf
    2. Ba ruler
    3. Creplanting in fresh soil
    4. Dlaboratory testing or an antibody test kit
    ( )
  9. 9

    The role of the tumour cell in hybridoma production is to

    1. Aprovide the antibody
    2. Bprovide rapid division
    3. Cprovide antigens
    4. Dprovide antibiotics
    ( )
  10. 10

    One evaluated drawback of monoclonal antibody therapy is

    1. Ait works on every cancer
    2. Bit has no side effects
    3. Cmore side effects occurred than expected
    4. Dit is always cheaper than chemotherapy
    ( )

Section B: Structured questions[20 marks]

Answer all questions in the spaces provided.

  1. 11

    This question is about monoclonal antibodies.

    1. (a)

      Describe how hybridoma cells are produced.

      [3]
    2. (b)

      Explain two medical uses of monoclonal antibodies.

      [3]
  2. 12

    A gardener finds that a rose bush is growing poorly, with purple-black spots on its leaves.

    1. (a)

      Name the disease and its pathogen type.

      [2]
    2. (b)

      Explain how the disease spreads to nearby bushes.

      [1]
    3. (c)

      State two actions the gardener should take.

      [2]
  3. 13

    This question is about the culturing practical.

    1. (a)

      Describe two aseptic precautions and what each prevents.

      [2]
    2. (b)

      Explain why incubating school cultures above 25 °C is not advised.

      [2]
  4. 14

    Two disinfectants are tested on plates spread with the same bacterium. Clear zones measure 16 mm across for disinfectant A and 24 mm across for disinfectant B.

    1. (a)

      Work out the area of each zone (πr²), to 3 significant figures.

      [4]
    2. (b)

      State which disinfectant is more effective.

      [1]

— End of paper —